Prof. RNDr. Aleš Stuchlík, DSc.
Odd. neurofyziologie paměti
Fyziologický ústav Akademie věd České Republiky
Vídeňská 1083, 142 20 Praha 4
Česká Republika
Skype: ales.stuchlik
Tel.:(+420) 296 442 577

Ales.Stuchlik@fgu.cas.cz

Publikace

Knihy
E-Book: Stuchlik, A., Sumiyoshi, T., eds. (2015).
Cognitive Deficits in Schizophrenia and other Neuropsychiatric Disorders: Convergence of Preclinical and Clinical Evidence.
Lausanne: Frontiers Media. doi: 10.3389/978-2-88919-679-1

Kapitoly v knihách
• Stuchlík A. Svět otištěný do paměťových stop. In: Horáček, J., Kesner, L., Höschl, C., Španiel, F. Mozek a jeho člověk, mysl a její nemoc. Praha: Galén, 2016, s. 33-40. ISBN: 978-80-7492-283-1.
• Fajnerová I, Vlček K, Brom C, Dvorská K, Levčík D, Konrádová L, Mikoláš P, Ungrmanová M, Bída M, Blahna K, Španiel F, Stuchlík A, Horáček J, Rodriguez M. Virtual Spatial Navigation Tests Based on Animal Research: Spatial Cognition Deficit in First Episodes of Schizophrenia. Book chapter in: Recent Advances on Using Virtual Reality Technologies for Rehabilitation. Paul M Sharkey & Joav Merrick (eds), Nova Publishing. Hauppauge NY, USA,, ISBN: 978-1-63484-027-9.
Stuchlik A, Tomas Petrasek, Hana Hatalová, Lukas Rambousek, Tereza Nekovarova and Karel Vales (2012). Behavioral Tests for Evaluation of Information Processing and Cognitive Deficits in Rodent Animal Models of Neuropsychiatric Disorders, Schizophrenia in the 21st Century, Dr. T.H.J. Burne (Ed.), ISBN: 978-953-51-0315-8, InTech, RIjeka, Croatia
• Nekovarova T, Stuchlik A, Vales K, Rambousek L, Sumiyoshi T: Cognitive Deficits in Pharmacological Rodent Models of Schizophrenia: Evaluation of Spatial Cognition: In "Schizophrenia Research: Recent Advances“. Editors: Tomiki Sumiyoshi, Nova Publishing, 2011, ISBN: 978-1-61942-459-3, pp. 291-319

Patenty
• Český patent (ÚPV) - Pregnanolone derivatives substituted in position 3alpha, process for their preparation and use. 2012. Date: 25.01.2012. Patent No.: 303037
• Český patent (ÚPV) - Pregnanolone derivatives substituted in position 3alpha with cationic group, process of their preparation, their use and composition containing them. Date: 02.08.2012. Patent No.: 303443
• PCT patent - Steroide anionic compounds, method of their production, usage and pharmaceutical preparation involving them. 05.11.2013. No. US8575376

Vybrané impaktované články:

• Uttl L, Petrasek T, Sengul H, Svojanovska M, Lobellova V, Vales K, Radostova D, Tsenov G, Kubova H, Mikulecka A, Svoboda J and Stuchlik A (2018)
Chronic MK-801 Application in Adolescence and Early Adulthood: A Spatial Working Memory Deficit in Adult Long-Evans Rats But No Changes in the Hippocampal NMDA Receptor Subunits.
Front. Pharmacol. 9:42. doi: 10.3389/fphar.2018.00042

• Svoboda J, Popelikova A, Stuchlik A.
Drugs Interfering with Muscarinic Acetylcholine Receptors and Their Effects on Place Navigation.
Front Psychiatry. 2017 ;8:215. doi: 10.3389/fpsyt.2017.00215. IF = 3.532 (2016)

• Szczurowska E, Ahuja N, Jiruška P, Kelemen E, Stuchlík A.
Impairment of neural coordination in hippocampal neuronal ensembles after a psychotomimetic dose of dizocilpine.
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Sep 18. pii: S0278-5846(17)30246-4. doi: 10.1016/j.pnpbp.2017.09.013. IF = 4.187 (2016)

• Pistikova A, Brozka H, Bencze M, Radostova D, Vales K, Stuchlik A.
The effect of hypertension on adult hippocampal neurogenesis in young adult spontaneously hypertensive rats and Dahl rats.
Physiol Res. 2017, 66(5):881-887. IF = 1.461 (2016)

• Pistikova A, Brozka H, Stuchlik A.
Adult neurogenesis in the hippocampus from a perspective of discrimination and generalization: a hypothesis.
Physiol Res. 2017; 66(3):441-448. IF = 1.461 (2016)

• Brozka H, Pistikova A, Radostova D, Vales K, Svoboda J, Grzyb AN, Stuchlik A.
Adult Neurogenesis Reduction by a Cytostatic Treatment Improves Spatial Reversal Learning in Rats.
Neurobiol Learn Mem. 2017 141: 93-100. doi: 10.1016/j.nlm.2017.03.018. IF = 3.543 (2016)

• Horak M, Holubova K, Nepovimova E, Krusek J, Kaniakova M, Korabecny J, Vyklicky L, Kuca K, Stuchlik A, Ricny J, Vales K, Soukup O.
The pharmacology of tacrine at N-methyl-d-aspartate receptors.
Prog Neuropsychopharmacol Biol Psychiatry. 2017; 75:54-62. doi: 10.1016/j.pnpbp. 2017.01.003 IF = 4.187 (2016)

• Svoboda J, Lobellová V, Popelíková A, Ahuja N, Kelemen E, Stuchlík A.
Transient inactivation of the anterior cingulate cortex in rats disrupts avoidance of a dynamic object.
Neurobiol Learn Mem. 2017. 139 (2017) 144–148 doi: 10.1016/j.nlm.2017.01.003, IF = 3.543 (2016)

• Buchtová H, Fajnerová I, Stuchlík A, Kubík Š.
Acute systemic MK-801 induced functional uncoupling between hippocampal areas CA3 and CA1 with distant effect in the retrosplenial cortex.
Hippocampus. 2017. 27:134–144 (2017) doi: 10.1002/hipo.22678 IF = 3.945 (2016).

• Laczo J, Markova H, Lobellova V, Gazova I, Parizkova M, Cerman J, Nekovarova T, Vales K, Klovrzova S, Harrison J, Windisch M, Vlcek K, Svoboda J, Hort J, Stuchlik A.
Scopolamine disrupts place navigation in rats and humans: a translational validation of the Hidden Goal Task in the Morris water maze and a real maze for humans.
Psychopharmacology. 2016. 234(4):535-547. doi: 10.1007/s00213-016-4488-2. IF = 3.308 (2016).

• Zach P, Vales K, Stuchlik A, Cermakova P, Mrzilkova J, Koutela A, Kutova M.
Effect of stress on structural brain asymmetry.
Neuroendocrinology Letters. 2016; 37(4): 253-264. IF = 0.918 (2016).

Stuchlik A, Radostová D, Hatalova H, Vales K, Nekovarova T, Koprivova J, Svoboda J, Horacek J.
Validity of Quinpirole Sensitization Rat Model of OCD: Linking Evidence from Animal and Clinical Studies.
Frontiers in Behavioral Neuroscience. 2016; 10: 209. doi: 10.3389/fnbeh.2016.00209. IF = 3.104 (2016).

• Hatalova H, Radostova D, Pistikova A, Vales K, Stuchlik A.
Detrimental effect of clomipramine on hippocampus-dependent learning in an animal model of obsessive-compulsive disorder induced by sensitization with D2/D3 agonist quinpirole.
Behavioural Brain Research. 2017; 317: 210-217. doi: 10.1016/j.bbr.2016.09.042. IF = 3.002 (2016).

• Duda W, Wesierska M, Ostaszewski P, Vales K, Nekovarova T, Stuchlik A.
MK-801 and memantine act differently on short-term memory tested with different time-intervals in the Morris water maze test.
Behavioural Brain Research. 2016; 311: 15-23. doi: 10.1016/j.bbr.2016.05.024. IF = 3.002 (2016).

• Petrasek T, Skurlova M, Maleninska K, Vojtechova I, Kristofikova Z, Matuskova H, Sirova J, Vales K, Ripova D, Stuchlik A.
A Rat Model of Alzheimer's Disease Based on Abeta42 and Pro-oxidative Substances Exhibits Cognitive Deficit and Alterations in Glutamatergic and Cholinergic Neurotransmitter Systems.
Frontiers in Aging Neuroscience. 2016; 8: 83. doi: 10.3389/fnagi.2016.00083. IF = 4.504 (2016).

• Holubova K, Kleteckova L, Skurlova M, Ricny J, Stuchlik A, Vales K.
Rapamycin blocks the antidepressant effect of ketamine in task-dependent manner.
Psychopharmacology. 2016; 233(11): 2077-2097. IF = 3.308 (2016).

• Vojtechova I, Petrasek T, Hatalova H, Pistikova A, Vales K, Stuchlik A.
Dizocilpine (MK-801) impairs learning in the active place avoidance task but has no effect on the performance during task/context alternation.
Behavioural Brain Research. 2016; 305: 247-57. doi: 10.1016/j.bbr.2016.03.020. IF = 3.002 (2016).

• Vevera J, Valeš K, Fišar Z, Hroudová J, Singh N, Stuchlík A, Kačer P, Nekovářová T.
The effect of prolonged simvastatin application on serotonin uptake, membrane microviscosity and behavioral changes in the animal model.
Physiology & Behavior. 2016; 158: 112-120. doi: 10.1016/j.physbeh.2016.02.029. IF = 2.341 (2016).

• Bahník Š, Stuchlík A.
Temporal and spatial strategies in an active place avoidance task on Carousel: a study of effects of stability of arena rotation speed in rats.
PeerJ. 2015; 3: e1257. doi: 10.7717/peerj.1257. IF = 2.183 (2015).

• Šlamberová R, Pometlová M, Macúchová E, Nohejlová K, Stuchlík A, Valeš K.
Do the effects of prenatal exposure and acute treatment of methamphetamine on anxiety vary depending on the animal model used?
Behavioural Brain Research. 2015; 292: 361-369. IF = 3.002 (2015).

Svoboda J, Telensky P, Blahna K, Vodicka M, Stuchlik A.
The role of rat posterior parietal cortex in coordinating spatial representations during place avoidance in dissociated reference frames on a continuously rotating arena (Carousel).
Behav Brain Res. 2015; 292:1-9. IF = 3.1 (2014)

Svoboda J, Stankova A, Entlerova M, Stuchlik A.
Acute administration of MK-801 in an animal model of psychosis in rats interferes with cognitively demanding forms of behavioral flexibility on a rotating arena.
Front Behav Neurosci. 2015; 9:75. IF = 3.3 (2014)

Fajnerová I, Rodriguez M, Levčík D, Konrádová L, Mikoláš P, Brom C, Stuchlík A, Vlček K, Horáček J:
A virtual reality task based on animal research – spatial learning and memory in patientsafter the firstepisode of schizophrenia.
Frontiers in Behavioral Neuroscience. Roč. 8, May 27 (2014), s. 157. ISSN 1662-5153, IF=4,2

Fajnerová I, Kenney J, Lobellová V, Okrouhlicová Š, Stuchlík A, Klement D:
Can rats solve the active place avoidance task without the room-bound cues?
Behavioural Brain Research. Roč. 267, Jul 1 (2014), s. 126-132. ISSN 0166-4328, IF=3,3

Hatalová H, Radostová D, Pištíková A, Valeš K, Stuchlík A:
Spatial reversal learning in chronicallysensitized rats and in undrugged sensitized rats with dopamine D2-like receptor agonist quinpirole.
Frontiers in Behavioral Neuroscience. Roč. 8, APR 11 (2014), s. 122. ISSN 1662-5153, IF=4,2

Holubová K, Nekovářová T, Pistovčáková J, Šulcová A, Stuchlík A, Valeš K:
Pregnanolone glutamate, a novel use-dependent NMDA receptor inhibitor, exertsantidepressant-like properties in animal models.
Frontiers in Behavioral Neuroscience. Roč. 8, Apr 16 (2014), s. 130. ISSN 1662-5153, IF=4,2

Kletečková L, Tsenov G, Kubová H, Stuchlík A, Valeš K:
Neuroprotective effect of the 3 alpha 5 beta-pregnanolone glutamatetreatment in the model of focalcerebralischemia in immature rats.
Neuroscience Letters. Roč. 564, APR 3 (2014), s. 11-15. ISSN 0304-3940

Kubík Š, Buchtová H, Valeš K, Stuchlík A:
MK-801 impairs cognitive coordination on a rotating arena (Carousel) and contextual specificity of hippocampal immediate-early gene expression in a rat model of psychosis.
Frontiers in Behavioral Neuroscience. Roč. 8, Mar 12 (2014), s. 75. ISSN 1662-5153, IF=4,2

• Mikulecká A, Šubrt M, Stuchlík A, Kubová H:
Consequences of early postnatalbenzodiazepinesexposure in rats. I. Cognitive-like behavior.
Frontiers in Behavioral Neuroscience. Roč. 8, Mar 28 (2014), s. 101. ISSN 1662-5153, IF=4,2

Nekovářová T, Yamamotová A, Valeš K, Stuchlík A, Fricová J, Rokyta R:
Commonmechanisms of pain and depression: are antidepressants also analgesics?
Frontiers in Behavioral Neuroscience, Roč. 8, Mar 25 (2014), s. 99. ISSN 1662-5153, IF=4,2

Petrásek T, Prokopová I, Sládek M, Weissová K, Vojtěchová I, Bahník Š, Zemanová A, Schönig K, Berger S, Tews B, Bartsch D, Schwab M, Sumová A, Stuchlík A:
Nogo-A-deficient Transgenic Rats Show Deficits in Higher Cognitive Functions, Decreased Anxiety, and AlteredCircadianActivityPatterns. Frontiers in Behavioral Neuroscience. Roč. 8, Mar 18 (2014), s. 90. ISSN 1662-5153

Petrásek T, Prokopová I, Bahník S, Schönig K, Berger S, Valeš K, Tews B, Schwab M. E, Bartsch D, Stuchlík A:
Nogo-A downregulationimpairs place avoidance in the Carousel maze but not spatial memory in the Morris water maze.
Neurobiology of Learning and Memory. Roč. 107, Jan 2014 (2014), s. 42-49. ISSN 1074-7427

Rambousek L, Páleníček T, Valeš K, Stuchlík A:
The effect of psilocin on memory acquisition, retrieval, and consolidation in the rat.
Frontiers in Behavioral Neuroscience. Roč. 8, May 16 (2014), s. 180. ISSN 1662-5153, IF=4,2

Stuchlík A, Sumiyoshi T:
Editorial on Cognitive Deficits in Schizophrenia and OtherNeuropsychiatricDisorders: Convergence of Preclinical and Clinical Evidence.
Frontiers in Behavioral Neuroscience. Roč. 8, - (2014), s. 444. ISSN 1662-5153, IF=4,2

Stuchlík A:
Dynamic learning and memory, synaptic plasticity and neurogenesis: an update.
Frontiers in Behavioral Neuroscience. Roč. 8, APR 1 (2014), s. 106. ISSN 1662-5153, IF=4,2

Stuchlík A, Kubík Š, Vlček K, Valeš K:
Spatial navigation: implications for animal models, drugdevelopment and humanstudies.
Physiological Research. Roč. 63, Suppl.1 (2014), S237-S249. ISSN 0862-8408, IF=1,5

• Petrasek T, Prokopova I, Bahnik S, Schonig K, Berger S, Vales K, Tews B, Schwab ME, Bartsch D, Stuchlik A.
Nogo-A downregulation impairs place avoidance in the Carousel maze but not spatial memory in the Morris water maze. Neurobiol Learn Mem. 2013, 6;107C:42-49. IF= 3.327 (2012)

Stuchlík A, Petrásek T, Prokopová I, Holubová K, Hatalová H, Valeš K, Kubík S, Dockery C, Wesierska M.
Place avoidance tasks as tools in the behavioral neuroscience of learning and memory. Physiol Res. 2013,62 Suppl 1:S1-S19. IF = 1.531 (2012)

• Krištofiková Z, Vrajová M, Sírová J, Valeš K, Petrásek T, Schönig K, Tews B, Schwab M, Bartsch D, Stuchlík A, Rípová D.
N-Methyl-d-Aspartate Receptor - Nitric Oxide Synthase Pathway in the Cortex of Nogo-A-Deficient Rats in Relation to Brain Laterality and Schizophrenia. Front Behav Neurosci. 2013, IF=4.8 (2012)

• Lobellova V, Entlerova M, Svojanovska B, Hatalova H, Prokopova I, Petrasek T, Vales K, Kubik S, Fajnerova I, Stuchlik A.
Two learning tasks provide evidence for disrupted behavioural flexibility in an animal model of schizophrenia-like behaviour induced by acute MK-801: a dose-response study. Behav Brain Res. 2013;246:55-62. IF = 3.327

• Rambousek L, Bubenikova-Valesova V, Kacer P, Syslova K, Kenney J, Holubova K, Najmanova V, Zach P, Svoboda J, Stuchlik A, Chodounska H, Kapras V, Adamusova E, Borovska J, Vyklicky L, Vales K.
Cellular and behavioural effects of a new steroidal inhibitor of the N-methyl-d-aspartate receptor 3α5β-pregnanolone glutamate. Neuropharmacology. 2011 IF = 3.909 (2010)

• Telensky P, Svoboda J, Blahna K, Bures J, Kubik S, Stuchlik A.
Functional inactivation of the rat hippocampus disrupts avoidance of a moving object. Proc Natl Acad Sci U S A. 2011; 108(13): 5414-8. IF = 9,432 (2010)

• Bubenikova-Valesova V, Stuchlik A, Svoboda J, Bures J, Vales K.
Risperidone and ritanserin but not haloperidol block effect of dizocilpine on the active allothetic place avoidance task. Proceedings of the National Academy of Sciences of the USA, 2008; 105 (3): 1061-1066 IF = 9,380 (2008)

Plný seznam impaktovaných článků: PDF (otevře se v novém okně)


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